Taxonomic chronology of Cryptosporidium
Some historical milestones (good or bad)
19 November 2009
1907
1910
1911
1912
1913
1925
1929
1938
1947
1954
1955
1961
1963
1968
1969
Duszynski (1969, J Protozool 16: 581-585) names a new species, C. ctenosauris, from a
Costa Rican lizard, Ctenosaura similis. This is now considered to be Sarcocystis
ctenosauris (Duszynski, 1969) Levine & Tadros, 1980.
1971
1972
Pande et al. (1972, Acta Vet Acad Sci Hung 22: 231-234) report a new type
of Cryptosporidium sp. from pups based on the "intracellular" location
of the developmental stages. They term this species Hoareosporidium
pellerdyi. This is now considered to represent a Sarcocystis
sp.
1974
Proctor & Kemp (1974, J Protozool 21: 664-666) name C. anserinum as new from the
large intestine of a domestic goose, Anser anser. Oocyst sizes are never reported. Later,
Levine (1984, J Protozool 31: 94-98) synonymizes this with C. meleagridis Slavin, 1955
even though the latter species develops in the small intestine. The species remains a nomen
nudum.
1976
1977
1979
Iseki (1979, Jap J Parasitol 28: 285-307) names C. felis from the domestic cat as new.
More recent evidence will indicate this to be a valid species.
1980
Levine (1980, J Parasitol 66: 830-834) creates the species C. rhesi for
Crytosporidium reported to infect the Rhesus monkey, and C. serpentis for the
species reported by Brownstein et al. (1977, Vet Pathol 14: 606-617) found to be pathogenic in
snakes. The former species should be regarded as a synonym of C.
parvum or C. hominis. The latter species, though considered
valid, technically
remains a nomen nudum in 1980 because of the lack of a proper
definitive description.
1981
Bird (1981, in Parasitol Topics, Soc Protozool Spec Publ 1, 39-47) names C. garnharmi as
new from humans. Although Levine (1984, J Protozool 31: 94-98) synonymizes this with C.
muris, it should be regarded as a synonym of C. parvum or
C. hominis.
1982
1984
1985
Qadripur & Klose (1985, Dermatol Monatsschr 171: 438-442) terms the
species infecting humans as "C. enteritidis". This term is
used later by several other european authors and should
be considered a
synonym of C. parvum.
1986
Paperna et al. (1986, Proc 39th Ann Meet, Soc Protozool, Univ Rhode
Island, Abstr 142) name Cryptosporidium villithecus as new from
cichlid fish. They do not use the nomen triviale and simply
refer to this species as C. sp. in
their formal paper (Landsberg & Paperna, 1986, Dis Aquat Org 2: 13-20).
1987
1989
Lindsay et al. (1989, Proc Helminthol Soc Wash 56: 91-92) presents
formal measurements for C. meleagridis that agree well with those
published earlier by Slavin (1955, J Comp Pathol 65: 262-266). This
clearly demonstrates that the species
is similar in size to C. parvum and smaller than C. baileyi.
1991
1993
1994
1995
Pavlasek et al. (1995, Gazella 22: 99-108) describe Cryptosporidium
varani n. sp.
for the intestinal Cryptosporidium sp. commonly found in reptiles,
particularly lizards. The type host is Varanus prasinus (Emerald
monitor). Later, Pavlasek (1997, Veterinarstvi
2: 63-65; 1998, Gazella 25: 163-170) reported the parasite
from additional hosts. Koudela and Modry (1998, Folia Parasitologica 45:
93-100), unaware of the work of Pavlasek, later decribe this same
species as Cryptosporidium saurophilum n. sp.
1996
1997
1998
Champliaud et al. (1998, Appl Environment Microbiol 64: 1454-1458)
use molecular techniques to reveal C. meleagridis and C.
parvum to be similar. Nonetheless, previous studies have shown that
the two species generally do not cross transmit between avian and
mammalian hosts.
Sargent et al. (1998, Vet Parasitol 77: 221-227) present morphologic and
molecular evidence to support the supposition that C. felis is a
distinct species.
Morgan et al. (1998, Parasitology 117: 31-37) present molecular evidence
that distinct porcine and murine genotypes exist that are morphologically
indisinguishable from C. parvum.
1999
Pieniazek et al. (1999, Emerg Inf Dis 5: 444-449)
present molecular evidence suggesting C. felis
to occur in an AIDS patient.
Carreno et al. (1999, Parasitol. Res. 85: 899-904)
present molecular evidence suggesting Cryptosporidium spp. are more
closely allied to the gregarines than to the coccidia proper.
Morgan et al. (1999, J. Parasitol. 85: 1126-1133)
present molecular evidence suggesting that Cryptosporidium
spp. from marsupials, and some isolates from swine, may represent distinct
species.
Patel et al. (1999, Int. J. Parasitol. 29: 1241-1247) report an unusual
genotype of Cryptosporidium from a single human, which eventually
turns out to be similar or identical to C. meleagridis
(Pedraza-Diaz et al. 2000, FEMS Microbiol Lett 189: 189-194).
Pavlasek (1999, Remedia-Klinicka Mikrobiol. 3: 290-301) describes a large Cryptosporidium sp.
from the proventriculus of chickens as Cryptosporidium galli n. sp. He later provides more
data on this parasite (2001, Veterinarstvi 51: 103-108).
2000
Lindsay et al. (2000, J. Euk. Microbiol. 47: 91-95)
present morphologic, molecular, and in vivo evidence that demonstrates
the large abomasal species in cattle to be distinct from
C. muris (researchers in Japan have been saying this for over a
decade). The name C. andersoni sp. n. is proposed.
Morgan et al. (2000, Appl. Environ. Microbiol. 66: 2220-2223)
present molecular evidence showing that dogs can be infected with a
distinct genotype of Cryptosporidium in addition to the classic
genotype 2.
Katsumata et al. (2000, Am. J. Trop. Med. Hyg. 62: 70-72)
present evidence of Cryptosporidium muris infecting humans. Multiple
reports since have confirmed that the parasite may infect some people.
2001
2002
Xiao et al. (2002, J. Inf. Dis. 185: 1846-1848) identify the pig genotype in
a human patient.
Morgan et al. (2002, J. Eukaryot. Microbiol. 49:
433-440) describe Cryptosporidium hominis sp. n. from humans. This
has been termed "C. parvum genotype I" previously.
2003
2004
2005
2006
2008
Jirku et al. (2008, Folia Parasitol. Praha, 55: 81-94) propose C.
fragile n. sp. for the species in toads. This may or may not be the
same species reported in 1987.
Fayer et al. (2008, Vet. Parasitol. 156: 191-198) propose C.
ryanae n. sp. for another species in cattle.
Pavlasek and Ryan (2008, Exper. Parasitol, 118: 434-437) show (once again)
that C. varani takes precedence over C. saurophilum.
2009
Tyzzer (1907, Proc Soc Exp Biol Med 5: 12-13) provides a brief but
adequate description (at the time) of
C. muris, the types species of the genus, from Mus musculus.
He establishes the genus Cryptosporidium.
Tyzzer (1910, J Med Res 23: 487-509) describes oocyst structure and
endogenous development
of Cryptosporidium muris from the gastric glands of experimentally
infected mice. The use
of control animals in his studies is noteworthy as it is not the norm at
the time.
Leger (1911, Arch Protistenkd 22: 71-88) establishes the family Cryptosporidiidae.
Tyzzer (1912, Arch Protistenkd 26: 394-412) describes a second member of
the genus, C. parvum, from mice as new. Morphological
descriptions of both the oocyst and developmental stages are reported.
Poche (1913, Arch Protistenkd 30: 125-321) also attempts to create the family Cryptosporidiidae
but is two years too late.
Triffit (1925, Protozoology 1: 19-26) names a new species, C.
crotali from the rattlesnake,
but it is now clear that this is a Sarcocystis sp.
Tyzzer (1929, Am J Hyg 10: 269-383) reports the finding of "Cryptosporidium parvum"
in the ceca of chickens. He is unsure whether his finding truly
represents C. parvum, and
provides no detailed information. It may or may not be
considered a synonym of C. baileyi Current, Upton, & Hayes, 1986.
Tyzzer also noted finding C. parvum in a rabbit which may be a
separate species.
Wetzel (1938, Arch Wiss Prakt Tierh 74: 39-40) describes C. vulpis as new from a fox. It
is now considered to be a Sarcocystis sp. (Levine & Tadros, 1980 Syst Parasitol 2: 41-59).
Matschoulsky (1947, Tr Buryat-Mongol Zoovet Inst 3: 93-101) reports C.
baikalika as new
from the woodcock. Line drawings reveal the parasite to represent gregarine oocysts.
Bearup (1954, Aust Vet J 30: 185-186) erroneously reports a Sarcocystis sp. as
Cryptosporidium sp. from a dog.
Slavin (1955, J Comp Pathol Ther 65: 262-266) names C. meleagridis as new from the
small intestine of the turkeys. A morphologic description of the
oocyst, and descriptions of the developmental stages, are reported. This
is still considered a valid species.
Levine (1961, Protozoan Parasites of Domestic Animals and of Man. 412 pp) names the
Cryptosporidiium sp. noted by Tyzzer (1929, Am J Hyg 10: 269-383) C. tyzzeri.
Since a description is still lacking, the species remains a nomen nudum.
Dubey & Pande (1963, Ind J Microbiol 3: 103-108) report a
Cryptosporidium sp. from the Indian jungle cat, Felis chaus.
This is now considered to represent a Sarcocystis sp.
Anderson et al. (1968, J Parasitol 54: 577-581) name C. lampropeltis as new from the
kingsnake, Lampropeltis calligaster. This is now termed Sarcocystis lampropeltis
(Anderson, Duszynski, & Marquardt, 1968) Levine & Tadros, 1980.
Arcay de Peraza & Bastardo de San Jose (1969, Acta Cient Venez 20: 125) name C.
ameivae as new from the lizard, Ameiva ameiva, in Venezuela.
Since no proper
description has ever been published, this remains a nomen nudum.
Vetterling et al. (1971, J. Protozool. 18: 243-247; 248-260) names C.
wrairi as new from guinea pigs. No morphological details about the
oocyst are given.
Gottschalk (1972, Beit Vogelkunde 18: 61-69) reports a
Cryptosporidium sp. from the hawk, Accipiter gentilis.
This is now considered to represent a Sarcocystis sp.
Barker & Carbonell (1974, Z Parasitenkd 44: 289-298) describe as new C. agni from
lambs and C. bovis from calves. This, based solely on host
specificity.
Nime et al. (1976, Gastroenterology 70: 592-598) and Meisel et al. (1976,
Gastroenterology 70: 1156-1160) independently report
Cryptosporidium from humans
for the first time.
Brownstein et al. (1977, Vet Pathol 14: 606-617) report pathology from snakes infected with a
new Cryptosporidium sp. This is later named C. serpentis by Levine (1980, J
Parasitol 66: 830-834), and is still considered a valid species.
Inman & Takeuchi (1979, Vet Pathol 16: 89-95) name C. cuniculus from the ileum of a
rabbit as new. Levine (1984, J Protozool 31: 94-98) attempts to
synonymize this (erroneously) with C.
muris.
Tzipori et al. (1980, Inf Immun 30: 884-886) suggest that
Cryptosporidium may be a single-species genus (at least the
species in mammals that they studied).
Hoover et al. (1981, J Fish Dis 4: 425-428) name C. nasorum for a new
Cryptosporidium sp. found in Naso lituratus. Technically,
since definitive morphologic details are lacking,
this still remains a nomen nudum.
Tham et al. (1982, Avian Pathol 11: 619-626) reports a pathogenic Cryptosporidium sp.
throughout the respiratory and digestive tract of quail. Although as yet
unnamed and the life-cycle undetermined, this will probably
be found to represent a distinct species.
Levine (1984, J Protozool 31: 94-98) erroneously synonymizes C. parvum with C.
muris. He also erroneously synonymizes C. rhesi with C. muris rather than
C. parvum, "C. tyzzeri" with C. meleagridis, and C. serpentis with
"C. crotali".
Upton & Current (1985, J Parasitol 71: 625-629) "unsynonymize" C. parvum and C.
muris. First published report of the large, abomasal C. sp. from cattle which is
erroneously termed C. muris in the paper (eventually to be named
C. andersoni). Complete morphologic
descriptions of C. parvum and the abomasal C. sp. from
cattle are provided. We now know there are many more species than
described.
Current et al. (1986, J Protozool 33: 289-296) describe C. baileyi as a new species from
the bursa and cloaca of chickens. Both a morphologic description and
complete life-cycle are provided. Since "C. tyzzeri" remains a
nomen nudum, and
can be legally discarded by authors who present a proper description, "C. tyzzeri" is
synonymized. Cryptosporidium baileyi remains a valid species.
Crawshaw & Mehren (1987, Erkrank Zoot, 1987, Cardiff, pp. 353-362) report a
Cryptosporidium sp. from an amphibian (toad) for the first time.
Upton et al. (1989, J Wildlf Dis 25: 20-30) report oocyst measurements for C. serpentis
for the first time. Measurements of various
isolates suggest multiple Cryptosporidium spp.
exist in reptiles.
Tilley et al. (1991, Can J Microbiol 37: 949-952) first report oocyst measurements for C.
wrairi, which are indistinguishable from C. parvum, and establish low level infections
in mice. It is unknown whether C. wrairi should be regarded as a distinct species, or a
form of C. parvum.
Gajadhar (1993, Can Vet J 34: 115-116) and Bezuidenhout et al. (1993, J
South Afr Vet Assoc 64: 156-158) independently report a
Cryptosporidium sp. from ostriches.
Gajadhar (1994, Parasitol Res 80: 316-319) presents morphologic evidence
to suggest that the Cryptosporidium sp. in ostriches is a species
distinct from others and smaller than other known avian
Cryptosporidium spp.
Morgan et al. (1995, Am J Trop Med Hyg 52: 539-564) uses RAPD analysis and suggests two
distinct genotypes infecting humans.
Paperna & Vilenkin (1996, Dis Aquat Org 27: 95-101) create a new genus and species,
Piscicryptosporidium reichenbachklinkei for a species of Cryptosporidium in the
gourami, Trichogaster leeri. It is unknown as this time whether this species is distinct
from C. nasorum and whether piscine Cryptosporidium spp.
deserve generic status.
Peng et al. (1997, Emerg Inf Dis 3: 567-573) also reports two distinct genotypes, and perhaps
species, of Cryptosporidium exist that may infect humans. Suggests 1993 Milwaukee
outbreak may not be due to bovine fecal contamination.
Koudela & Modry (1998, Folia Parasitol 45: 93-100) describe C. saurophilum as new
from the skink, Eumeces schneideri. Oocysts are smaller than for
C. serpentis. This species should be regarded as a synonym of
Cryptosporidium varani Pavlasek, Lavickova, Horak, Kral, and Kral,
1995.
Bornay-Llinares et al. (1999, Appl Environment Microbiol 65: 1455-1458)
present molecular and morphological evidence suggesting C. felis
to occur in a cow.
Morgan et al. (2000, Parasitology 120: 457-464)
present molecular evidence showing Cryptosporidium muris and
C. andersoni to be genetically distinct.
Fayer et al. (2001, J. Parasitol. 87: 1415-1422) describe
Cryptosporidium canis sp. n. from canids.
Alvarez-Pellitero and Sitja-Bobadilla (2002, Int. J. Parasitol. 32:
1007-1021) describe Cryptosporidium molnari sp. n. from marine fish.
Ryan et al. (2003, J. Parasitol. 89: 809-813) redescribe Cryptosporidium galli Pavlasek, 1999
from birds.
Ryan et al. (2004, J. Parasitol. 90: 769-773) provide genetic and biological data to support
their description of Cryptosporidium suis n. sp. for one of
the two genotypes of Cryptosporidium spp. found in swine.
Fayer et al. (2005, J. Parasitol. 91: 624-629) provide genetic and
biological evidence for Cryptosporidium bovis n. sp., which
has previously been referred to as bovine genotype B and infects
older ruminants. This parasite was apparently first reported by Panciera
et al. (1971, Vet. Pathol. 8: 479-484).
Slapeta, J. (2006, Trends Parasitol. 22: 469-474) proposes that
Cryptosporidium pestis n. sp. be subsituted for C. parvum of
most mammals.
Ryan et al, (2008, J Euk Microbiol 55: 22-26) propose Cryptosporidium fayeri n. sp. for the
isolate from the red kangaroo.
Fayer and Santini (2009, Vet. Parasitol. 164: 192-200) propose C.
xiaoi as a new species in sheep.
As you will note from the above, the taxonomic history of the genus
Cryptosporidium is a bit confusing and incomplete, and the
taxonomic
positions of several species remain unclear. In order to help resolve
taxonomic issues, and keep species from falling as synonyms, nomen
nuda, or nomen dubia, the following guidelines for
establishing new species are proposed:
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