Sherry Fleming

Assistant Professor

Ph.D. 1998, University of Colorado Health Science Center
Immunology

 

18A Ackert Hall
(785) 532-6130
sdflemin@ksu.edu

Molecular Cellular Developmental Biology Web

Description of Research

The focus of my laboratory is on the complement system and other innate immune molecules. Although beneficial during infections, these molecules can cause excessive tissue damage in other conditions. Projects in my laboratory will determine the damaging aspects of the innate immune response in multiple models of tissue injury.

Selected Research Publications

Anderson , J., S.D. Fleming, S. Rehrig, G.C.Tsokos, M. Basta.,and T. Shea-Donohue.  2004. Intravenous immunoglobulin attenuates mesenteric ischemia-reperfusion injury. Clin. Immunol. 114:137-146.

Fleming , S.D. , R.P. Egan, G. Girardi, V.M. Holers, J. Salmon, M. Monestier, and G.C. Tsokos. 2004. Anti-phospholipid antibodies restore mesenteric ischemia/reperfusion induced injury in complement receptor CR2/CR1 deficient mice.  J. Immunol. 173:7055-7063. 

Fleming , S.D. , M. Monestier, and G.C. Tsokos. 2004. Accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice. J. Immunol. 173: 4230-4235.

Fleming, S.D., J. Anderson, F.Wilson, T.Shea-Donohue and G.C. Tsokos.  2003.  C5 is required for CD49d expression on neutrophils and VCAM expression on vascular endothelial cells following mesenteric ischemia/reperfusion. Clin. Immunol. 106:55­64. 

Fleming , S.D. , D.  Mastellos, G. Karpel-Massler, T. Shea-Donohue, J. Lambris, and G.C. Tsokos. 2003. C5a causes limited, polymorphonuclear cell-independent, mesenteric ischemia/reperfusion-induced.  Clin.  Immunol. 108:263-273.

Fleming, S.D. and G.C. Tsokos.  2003.  Role of Complement in Trauma in Combat Medicine: Basic and Clinical Research in Military Trauma and Emergency Medicine. pp. 131-148 Ed. G.C. Tsokos and J. Atkins, Humana Press, Totowa, NJ.

Karpel-Massler, G., S.D. Fleming, M. Kirschfink, and G.C. Tsokos, . 2003.  Human C1 esterase inhibitor attenuates murine mesenteric ischemia/reperfusion induced local organ injury. J. Surg. Res. 115:247-256. 

Tsokos, G.C. and S.D. Fleming, 2003. Autoimmunity, complement activation, tissue injury and reciprocal effects. Curr. Dir. Autoimmun. 7: 149-164. 

Fleming, S.D., T.Shea-Donohue, J.M. Guthridge, L. Kulik, T.J. Waldschmidt, M.G. Gipson, G.C. Tsokos and V.M. Holers.  2002.  Mice deficient in complement receptors I and 2 lack a tissue injury-inducing subset of the natural antibody repertoire.  J. Immunol. 169:2126-21.3. 

Mukasa, A., Lahn, M.. Fleming, S., Freiberg, B., Pflum. E., Vollmer, M.. Kupfer, A, O'Brien, R., and W. Born.  2002.  Extensive and preferential Fas/Fas-ligand-dependent death of y6 T cells following infection with Listeria mono cvtogenes.  Scand. J. Immunol. 56:233-247. 

Fleming, S.D., B. Starnes, J.G. Kiang, A. Stojadinovic, G.C. Tsokos, and T.Shea­Donohue.  2002. Heat stress protection against mesenteric ischemia/reperfusion - induced alterations in intestinal mucosa in rats.  J. Applied Physiol. 92:2600-2607. 

Rehrig, S.. S.D. Fleming, J. Anderson, J.M. Guthridge, J. Rakstang, C. McQueen, V.M. Holers, G.C. Tsokos. and T.Shea-Donohue.  2001.  Complement inhibitor, Crry­Ig attenuates intestinal damage after the onset of mesenteric ischemia'reperfusion injury in mice.  J. Immnunol. 167: 5921-5927. 

Fleming, S.D. and G.C. Tsokos.  2001.  Complement Inhibitors in Rheumatic Diseases in Modern Therapeutics in Rheumatic Diseases.  Pg 443-452. Ed. G.C. Tsokos. Humana Press, Totowa, NJ. 

Fleming, S.D., S. Toratani, T. Shea-Donohue, Y. Kashiwabara, S.N. Vogel, E. S. Metcalf.  2000.  Pro- and anti-inflammatory gene expression in the murine small intestine and liver after chronic exposure to alcohol.  Alcohol Exp. Clin. Res. 25:579­590. 

Fleming, S.D., P.L.M. Leenen, J.H. Freed, P.A. Campbell.  1999.  Murine macrophage cell surface IL-10 inhibits listericidal activity.  J. Leuko. Biol. 66:961-967.