http://www.ksu.edu/biology K-State Division of Biology
chapes

Rollie J. Clem

Associate Professor

Ph.D. 1994, University of Georgia. Virology and Oncology.

Regulation of apoptosis; molecular biology of baculoviruses.

 


268 Chalmers Hall
785-532-3172
rclem@ksu.edu

K-State Molecular Virology Web


Selected Research Publications

Clem, R.J. 2005.  The role of apoptosis in defense against baculovirus infection in insectsCurr. Top. Microbiol. Immunol. 289:113-130.

Green, M.C., K.P. Monser, and R.J. Clem. 2004.  Ubiquitin protein ligase activity of the anti-apoptotic baculovirus protein Op-IAP3Virus Res. 105:89-96.

Muro, I., K. Monser, and R.J. Clem.  2004.  Mechanism of Dronc activation in Drosophila cells. J. Cell Sci. 117:5035-5041.

Clarke, T.E. and R.J. Clem. 2003. Insect defenses against virus infection: The role of apoptosisInt. Rev. Immunol. 22:401-424.

Clarke, T.E. and R.J. Clem.  2003.  In vivo induction of apoptosis correlating with reduced infectivity during baculovirus infectionJ. Virol. 77:2227-2232.

Means, J.C., I. Muro, and R.J. Clem.  2003.  Silencing of the baculovirus Op-iap3 gene by RNA interference reveals that it is required for preventing apoptosis during Orgyia pseudotsugata M nucleopolyhedrovirus infection of Ld652Y cellsJ. Virol. 77:4481-4488.

Clarke, T.E. and R.J. Clem. 2002.  Lack of involvement of hemocytes in the establishment and spread of infection in Spodoptera frugiperda larvae infected with the baculovirus AcMNPV by intrahemocoelic injection. J. Gen. Virol. 83:1565-1572.

Clem, R. J.  2001.  Baculoviruses and apoptosis: The good, the bad, and the uglyCell Death and Differentiation 8:137-143.

Muro, I., Hay, B.A., and R.J. Clem. 2002. The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONCJ. Biol. Chem. 277:49644-49650.

Wright, C.W. and R.J. Clem. 2002. Sequence requirements for Hid binding and apoptosis regulation in the baculovirus inhibitor of apoptosis Op-IAP: Hid binds Op-IAP in a manner similar to Smac binding of XIAP. J. Biol. Chem. 277:2454-2462.

Yoo, S.J., Huh, J.R., Muro, I., Yu, H., Wang, L., Wang, S.L., Feldman, R.M.R., Clem, R.J., Muller, H.-A.J., and B.A. Hay.  2002.  Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms. Nature Cell Biol. 4:416-424.


HomePeopleAcademicsResearchMake a GiftContact Us

©2007 Division of Biology, Kansas State University SiteMap